Jolanda van der Velden

This study shows that microtubule detyrosination in HCM causes nuclear shape changes and YAP1 signaling, which can be reversed by inhibiting detyrosination.

The paper identifies altered microtubule post-translational modifications in hypertrophic cardiomyopathy and shows protein kinase A modulates microtubule repolymerization in patient-derived hiPSC-CMs.

This paper identifies a nanodomain mechanism regulating troponin I phosphorylation and demonstrates a peptide that selectively enhances relaxation without compromising systolic function in heart failure.

This study analyzes heart tissue from BTHS patients using integrated omics to identify metabolic and mitochondrial changes associated with the disease.

This study identifies NUAK1 as a regulator of vascular smooth muscle cell contraction in abdominal aortic aneurysm patients, showing its role in modulating MYPT1 activity and contraction-related proteins.