Alex A. Henneman

This study shows that EGFR inhibition in glioblastoma does not lead to broad kinome rewiring but instead results in increased EGFR abundance and partial restoration of EGFR signaling.

The paper identifies altered microtubule post-translational modifications in hypertrophic cardiomyopathy and shows protein kinase A modulates microtubule repolymerization in patient-derived hiPSC-CMs.

The paper introduces a new data structure and fragment weighting method to improve the speed and accuracy of protein quantification in mass spectrometry-based proteomics.

CellEKT profiles cellular target engagement of kinase inhibitors using chemical proteomics to determine IC50 values across over 300 kinases and validate results with phosphoproteomics and NanoBRET.

This study identifies NUAK1 as a regulator of vascular smooth muscle cell contraction in abdominal aortic aneurysm patients, showing its role in modulating MYPT1 activity and contraction-related proteins.

INKA identifies active phosphokinases in cancer by integrating kinase and substrate phosphorylation data from phosphoproteomics.