Stephen Howard Leppla

This study identifies BAS PrkA, a novel AAA+ ATPase in B. anthracis, which is essential for sporulation and osmotic stress response, despite lacking detectable enzymatic activity.

This study identifies how glucose and CO2 synergistically regulate toxin production in Bacillus anthracis through the AtxA transcription factor and its interaction with the glucose-PTS system.

This study defines the epitope, specificity, and mechanism of the J2 monoclonal antibody, revealing its unique recognition of dsRNA and implications for RNA research.

This paper shows anthrax toxin can target and modulate pain by acting on nociceptive neurons through ANTXR2, with potential for new pain therapeutics.