Sundar Ganesan

A novel AAA+ ATPase required for sporulation and stress response in Bacillus anthracis

This study identifies BAS PrkA, a novel AAA+ ATPase in B. anthracis, which is essential for sporulation and osmotic stress response, despite lacking detectable enzymatic activity.

A PI3Kδ-Foxo1-FasL signaling amplification loop rewires CD4+ T helper cell signaling, differentiation and epigenetic remodeling

The paper identifies a PI3Kδ-Foxo1-FasL signaling loop that disrupts Th2 differentiation and epigenetic regulation in CD4+ T cells.

Environmental Regulation of Toxin Production in Bacillus anthracis

This study identifies how glucose and CO2 synergistically regulate toxin production in Bacillus anthracis through the AtxA transcription factor and its interaction with the glucose-PTS system.

Optimal CXCR5 Expression during Tfh Maturation Involves the Bhlhe40-Pou2af1 Axis

This study identifies the Bhlhe40-Pou2af1 axis as a transcriptional regulator of CXCR5 expression in Tfh cells, independent of the Bcl6-Blimp1 pathway.

Kupffer cell and recruited macrophage heterogeneity orchestrate granuloma maturation and hepatic immunity in visceral leishmaniasis

The paper shows that macrophage heterogeneity, including resKC-derived and monocyte-derived cells, is critical for granuloma maturation and parasite control in visceral leishmaniasis.

Human ESCRT-I and ALIX function as scaffolding helical filaments in vivo

This study shows ESCRT-I and ALIX form helical filaments in vivo, serving as structural scaffolds and ESCRT-III assembly templates for membrane scission and viral budding.

MATRIN3 deficiency triggers autoinflammation via cGAS-STING activation

This study identifies MATRIN3 deficiency as a trigger for autoinflammation through cGAS-STING activation via mis-splicing of TDRD3 and R-loop formation.