Author

Saikiran K. Sedimbi

Karolinska InstitutetORCID 0000-0001-5243-8395Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:experimental assay· 1 Organism:mouse· 1

Frequent Co-Authors

Christina SeitziD· 1 shared Daisuke KitamuraiD· 1 shared Evangelos DoukoumopoulosiD· 1 shared José J. FusteriD· 1 shared Lena StrömiD· 1 shared Lia Gonçalves PinhoiD· 1 shared Lisa S. WesterbergiD· 1 shared María A. ZuriagaiD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperImmunology

Christina SeitzORCID

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1 paper

Recent·Most cited

AID facilitates TET2 demethylation of Irf4 for plasma cell fate in germinal center B cells

Minghui He, Roberta D’Aulerio, Lia Gonçalves Pinho, Evangelos Doukoumopoulos, Tracer Yong, Rhaissa Calixto Vieira, Mariana M. S. Oliveira, Rômulo Gonçalves Agostinho Galvani, Saikiran K. Sedimbi, Christina Seitz, Nikolai V. Kuznetsov, María A. Zuriaga, Daisuke Kitamura, José J. Fuster, Vinı́cius Cotta-de-Almeida, , Lisa S. Westerberg

This study shows AID deficiency in B cells leads to reduced IRF4 expression and impaired plasma cell differentiation due to disrupted TET2-mediated demethylation of the Irf4 promoter.

bioRxiv · May 2, 2025 · PreprintImmunology