George S. Melchor

This study shows that fibroblasts accumulate in demyelinated spinal cord lesions in mice, excluding oligodendrocyte precursor cells, and this effect is more pronounced with age.

This study shows that senescent microglia impair remyelination in young mice but not aged mice, with CCL11 in SASP inhibiting oligodendrocyte maturation.

The paper analyzes gene expression dynamics in a remyelinating microenvironment using single nucleus RNA sequencing in mice, revealing shifts in microglial, astrocytic, and fibroblast activities linked to oligodendrocyte differentiation.