Jeffrey K. Huang

This study shows that fibroblasts accumulate in demyelinated spinal cord lesions in mice, excluding oligodendrocyte precursor cells, and this effect is more pronounced with age.

This study investigates how IL4I1 affects lymphocyte activity in healthy individuals and MS patients, finding it promotes regulatory T-cells in healthy samples but not in MS patients.

This study shows that senescent microglia impair remyelination in young mice but not aged mice, with CCL11 in SASP inhibiting oligodendrocyte maturation.

The paper analyzes gene expression dynamics in a remyelinating microenvironment using single nucleus RNA sequencing in mice, revealing shifts in microglial, astrocytic, and fibroblast activities linked to oligodendrocyte differentiation.

The paper shows that bryostatin-1, a PKC modulator, shifts microglia and CNS macrophages from pro-inflammatory to regenerative states, promoting remyelination and neuroprotection in MS.