Zhen Zhao

This study shows that delivering multiple cytokine and antigen mRNAs via nanoparticles can generate strong anti-tumor immunity against pancreatic cancer in mice.

This paper introduces PICASSO, a framework that makes pathology foundation models interpretable and controllable by decomposing embeddings into human-interpretable visual concepts, enabling new biological insights and downstream applications.

The paper identifies TREM2-expressing macrophages as predictors of response to PD-1 blockade in HCC patients using clinical and spatial transcriptomic data.

MARQO pipeline automates single-cell analysis of multiplex immunostained tissue slides, showing improved accuracy over manual methods in cancer studies.

This study identifies FGFR2 as a key driver in early pancreatic tumorigenesis, showing that its inhibition can delay tumor formation and extend survival in mouse models.