Astrid Deschênes

The paper introduces RAIDS, a toolset for inferring genetic ancestry from various sequence data, including cancer and low-coverage scenarios.

This paper develops an ancestrally inclusive patient-derived organoid platform for UCS that captures cancer cell plasticity and identifies therapeutic vulnerabilities.

The paper identifies a MYC-USP39-SRSF1 regulatory axis in PDAC that stabilizes SRSF1 and promotes tumor progression, suggesting USP39 as a therapeutic target.

This study characterizes the molecular differences in high-grade endometrial cancer across an ancestrally diverse cohort, identifying ancestry-associated mutations and immune microenvironment differences.

This study identifies FGFR2 as a key driver in early pancreatic tumorigenesis, showing that its inhibition can delay tumor formation and extend survival in mouse models.

This study develops a data synthesis framework to accurately infer genetic ancestry from cancer-derived molecular data across genomic platforms, showing high accuracy across different sequencing depths and modalities.