Author

Zhen Zhao

National Institute of Biological Sciences, Beijing

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Biology Disciplines

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Cancer Biology· 1 Genomics· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Organism:mouse· 2 Research Focus:cell-cell communication· 1 Assay:CRISPR screen· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1

Frequent Co-Authors

Ahmed M. ElhossinyiD· 1 shared Andrea C. ChaikovskyiD· 1 shared Andrew R Moorman· 1 shared Andy Y. ShihiD· 1 shared Anusha MishraiD· 1 shared Aveline A. FillioliD· 1 shared Ben Zimmerman· 1 shared Bradley D. MarxmilleriD· 1 shared

Activity by Year

2026-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperCancer Biology

Ahmed M. ElhossinyORCID

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3 papers

Recent·Most cited

Reconstructing sequence-grammar trajectories enables interpretable and tunable cis-regulatory element design

Mingqian Ma, Wanjuan Bu, Guoqing Liu, Yuxuan Liu, Liu S, Zhen Zhao, Shijie Yao, Qingru Hua, Yu Zhang, Cuiting Zhong, Haitao Huang, Pan Deng, Peiran Jin, Qijin Yin, Chuan Cao, , Zeyu Chen

This paper introduces GO-CRE, a method for designing cell-type-specific cis-regulatory elements by reconstructing sequence-grammar trajectories and using reinforcement learning with predictor guidance.

bioRxiv · Jul 17, 2026 · PreprintGenomics

Oncogenic and tumor-suppressive forces converge on a progenitor niche at the benign-to-malignant transition

Jose Reyes, Isabella S. Del Priore, Andrea C. Chaikovsky, Nikhita Pasnuri, Ahmed M. Elhossiny, Jin Park, Philipp Weiler, Tobias Krause, Andrew R Moorman, Catherine Snopkowski, Meril T. Takizawa, Cassandra Burdziak, Nalin Ratnayeke, Ignas Masilionis, Yu-Jui Ho, , Scott W. Lowe

In mouse pancreatic cancer models, p53, CDKN2A and SMAD4 programs converge on a rare Kras-mutant progenitor-like state whose niche KRAS inhibition collapses and p53 loss expands.

Cell · Apr 15, 2026Peer-reviewedCancer Biology✦ In-depth digest

Chemogenetic Pericyte Activation Reveals Broad Contractile Ability and Limbic Vulnerability to Capillary Flow Deficits

Liam T. Sullivan, Dickson T. Chen, Catherine Foster, Ben Zimmerman, Kevin J Elk, Bradley D. Marxmiller, Taylor McGillis, Yuandong Li, Stephanie K. Bonney, Lila D. Faulhaber, Dimitrios Davalos, Juliane Gust, Zhen Zhao, Anusha Mishra, Andy Y. Shih

This study uses chemogenetic activation of pericytes in mice to show their ability to contract capillaries and cause hypoperfusion, particularly in limbic regions.

bioRxiv · Apr 14, 2026 · PreprintNeuroscience