APOE4 disrupts the central dogma by arresting neuronal proteome dynamics
Einar Kleinhans Krogsaeter, Justin McKetney, Lishi Li, Isabelle Liu, Alicia Richards, Vishvak Subramanyam, Keyi Yin, Martin Gordon, Pedro Belio Mairal, Erica J. Stevenson, Houzhen Qian, Yadong Huang, Hani Goodarzi, Nevan J. Krogan, Danielle L. Swaney
This study shows APOE4 disrupts neuronal proteome dynamics by impairing proteostasis, leading to protein accumulation and cellular stress before Alzheimer's disease onset.
bioRxiv · Jul 22, 2026 · PreprintNeuroscience