Christiane E. Wobus

This study shows polyamine depletion inhibits norovirus infection by blocking virus-induced apoptosis and virion release in both human and murine systems.

This paper identifies allosteric escape mutants of murine norovirus that constitutively adopt the activated conformation, providing insights for vaccine design.

This study identifies that the Norovirus NS1/2 protein enhances glutaminolysis to support viral replication in macrophages.

This study uses CRISPR screening to identify 35 genes that modify ACE2 surface abundance in HuH7 cells, revealing regulators of ACE2 expression and their impact on SARS-CoV-2 susceptibility.

This study shows that central carbon metabolism is essential for optimal murine norovirus replication and suggests metabolism as a therapeutic target for norovirus infections.

This study shows that natural secretory immunoglobulins (SIg) do not protect against murine norovirus infection and may indirectly promote infection by reducing antiviral molecules.