David Hike

This study develops a high-resolution 23Na-MRI platform using implanted RF coils to detect ischemic brain injury with improved contrast-to-noise ratio.

The paper analyzes vasomotor rhythms in awake mice using fMRI to show their multiscale propagation patterns across the cortex.

This paper introduces an ultra-high-resolution MRI framework to map perivascular spaces (PVS) across the whole brain, revealing their hierarchical organization along vascular trees.

This study uses high-field multinuclear MRI to analyze sodium relaxation heterogeneity in cortical organoids, revealing distinct relaxation components and spatial microenvironment variations.

This paper introduces NARS-fMRI, a method that detects millisecond neuronal activity via 23Na signal changes, showing it correlates with BOLD and glutamate transients in rodent somatosensory cortex.

This study shows that smooth muscle dysfunction caused by ACTA2 mutations leads to cerebrovascular reserve failure, increasing brain vulnerability to hypoperfusion and injury.

This study shows that mild perinatal hypoxia-ischemia causes delayed and prolonged neuronal death, with neurons dying later showing normal function and viability for days post-injury.

This paper develops a high-resolution awake mouse fMRI platform to map sensory processing in association cortices, revealing anticipatory brain activity during vibrissa stimulation.

This study uses high-resolution MRI to map glymphatic transport in deep brain regions by directly infusing Gd into the lateral ventricle and analyzing PVS signal enhancements.

The paper develops a deep learning-based method to segment micro-vessels from CBV MRI images of AD mice, revealing region-specific vascular density changes in degenerated brains.

The paper uses pupillary light response-driven fMRI in awake mice to identify brain-wide biomarkers of Alzheimer's disease by analyzing altered neuromodulatory patterns and functional connectivity.

This paper introduces a new fMRI method called SELINE to improve laminar-specific BOLD signal detection by reducing vein effects and improving spatial resolution.