Timothy Wu

This study uses a cross-species approach to identify gene expression networks linked to Alzheimer's disease pathology and neurodegeneration.

The paper uses single-cell RNA-sequencing in Drosophila to show that tau pathology and aging affect different cell types, with tau primarily impacting excitatory neurons and glia.

The paper identifies genetic modifiers of alpha-synuclein-mediated neurodegeneration by screening fly homologs of lysosomal storage disorder genes.

The paper analyzes transcriptome and proteome changes in a Drosophila tauopathy model, identifying age- and Tau-induced gene expression differences and their cross-species implications.

The paper analyzes whole blood transcriptomes in bipolar disorder patients and finds that lithium treatment, not the disorder itself, drives most gene expression changes.