Weiyi Tan

This paper shows that targeting cellular S-acylation with synthetic compounds can spatially disrupt KRAS signaling and stress responses in cancer cells.

The paper shows lipid imbalance creates Golgi whorls that sequester small GTPases, disrupting trafficking and viability.

This paper develops CyMA, small peptides that disrupt cancer cell Golgi function by exploiting enzymatic cycles, showing selectivity over hepatocytes and immune cells.

The paper introduces BODIPY-CyMA, a probe that uses enzymatic cycles for ultrasensitive Golgi imaging with low concentrations and minimal incubation.