Lei Lü

Cycling Molecular Assemblies for Selective Cancer Cell Golgi Disruption

This paper develops CyMA, small peptides that disrupt cancer cell Golgi function by exploiting enzymatic cycles, showing selectivity over hepatocytes and immune cells.

Cycling Molecular Assemblies (CyMA) for Ultrasensitive Golgi Imaging

The paper introduces BODIPY-CyMA, a probe that uses enzymatic cycles for ultrasensitive Golgi imaging with low concentrations and minimal incubation.

Knocking out Arl13b completely abolishes primary ciliogenesis

This study shows that complete ARL13B knockout in cultured cells abolishes ciliogenesis and hedgehog signaling, indicating a more critical role for ARL13B in ciliary function than previously thought.

Quantitative intra-Golgi transport and organization data suggest the stable compartment nature of the Golgi

The paper challenges the classical cisternal progression model by showing that intra-Golgi transport velocity varies and Golgi residence times differ for different cargos, suggesting a stable compartment model.