Qiuxin Zhang

Hijacking Cellular S-Acylation with Molecular Assemblies Rewires Oncogenic Signaling

This paper shows that targeting cellular S-acylation with synthetic compounds can spatially disrupt KRAS signaling and stress responses in cancer cells.

Lipid Imbalance Generates Golgi Whorls that Sequester Small GTPases

The paper shows lipid imbalance creates Golgi whorls that sequester small GTPases, disrupting trafficking and viability.

Cycling Molecular Assemblies for Selective Cancer Cell Golgi Disruption

This paper develops CyMA, small peptides that disrupt cancer cell Golgi function by exploiting enzymatic cycles, showing selectivity over hepatocytes and immune cells.

Cycling Molecular Assemblies (CyMA) for Ultrasensitive Golgi Imaging

The paper introduces BODIPY-CyMA, a probe that uses enzymatic cycles for ultrasensitive Golgi imaging with low concentrations and minimal incubation.

Peptides alleviate cognitive impairment by inhibiting and disassembling amyloid-beta aggregates in Alzheimer disease

The paper shows that specific peptides inhibit Aβ aggregation and reduce cognitive impairment in Alzheimer's disease models.