Abdulshakour Mohammadnia

This study shows that inflammation disrupts oligodendrocyte precursor cell lipid metabolism, impairing remyelination, and that activating liver X receptors can restore lipid balance and promote myelin repair.

This study shows fibrinogen has opposing effects on human oligodendrocyte lineage cells depending on their maturation stage, inhibiting early differentiation but enhancing myelination in mature cells.

The paper investigates how epigenomic factors like chromatin accessibility and histone modifications affect human oligodendrocyte myelination and age-related vulnerability to injury.

This study shows that TNF and IFNγ inhibit human OPC differentiation into oligodendrocytes and promote an astrocyte-like reactive phenotype, potentially contributing to impaired myelin repair in MS.

This study identifies a senescent-like phenotype in neurons under inflammation and shows that rejuvenation improves survival in an MS model.

This study identifies immune gene expression signatures in neurons from MS patients and EAE mice, revealing shared pathways and potential roles for IRF5 and STAT1 in neuronal inflammation.