Jacob S. Roth

The paper shows PRMT5 promotes chromatin escape of mRNAs by methylating SNRPB, affecting splicing and nuclear export.

This study shows PRMT5 sustains histone transcription and protein synthesis during S phase, maintaining genome integrity by regulating histone H4 methylation.

This study identifies ADC payloads transported by ABC transporters, showing potential for drug resistance and suggesting payload selection to avoid this.

This study shows that CARM1 loss in GSCs disrupts developmental programming, shifts lineage towards radial glia, and creates a dependency on NGFR/NTRK signaling, making them vulnerable to NTRK inhibitors.