Chronic exposure to low-concentration urban PM2.5 accelerates maladaptive repair after ischemic injury via mitochondrial dysfunction and lysosomal stress.
Peiqi Sun, Antônio Carlos Parra, Talita Rojas Sanches, Caroline Fernanda Hei Wikuats, Loes M. Butter, Nike Claessen, Hans J. Baelde, Ireen Schimmel, Nicole N. van der Wel, Georges E. Janssens, Riekelt H. Houtkooper, Frédéric Maxime Vaz, Joris J. T. H. Roelofs, Peter Boor, Martin Strauch, , Alessandra Tammaro
This study shows that chronic low-concentration PM2.5 exposure after ischemic injury accelerates CKD through mitochondrial dysfunction and lysosomal stress, with nicotinamide reversing some effects.
bioRxiv · Mar 14, 2026 · PreprintMolecular Biology