Author

Joris J. T. H. Roelofs

Amsterdam UMC Location University of AmsterdamORCID 0000-0001-9595-6571Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Assay:electronic health records· 1 Organism:human· 1

Frequent Co-Authors

Alessandra TammaroiD· 2 shared Loes M. ButteriD· 2 shared Nike Claessen· 2 shared Alessia RomagnoloiD· 1 shared Anne C. HespiD· 1 shared Antônio Carlos ParraiD· 1 shared Caroline Fernanda Hei WikuatsiD· 1 shared Christopher Wall· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersMolecular Biology

Alessandra TammaroORCID

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2 papers

Recent·Most cited

Chronic exposure to low-concentration urban PM2.5 accelerates maladaptive repair after ischemic injury via mitochondrial dysfunction and lysosomal stress.

Peiqi Sun, Antônio Carlos Parra, Talita Rojas Sanches, Caroline Fernanda Hei Wikuats, Loes M. Butter, Nike Claessen, Hans J. Baelde, Ireen Schimmel, Nicole N. van der Wel, Georges E. Janssens, Riekelt H. Houtkooper, Frédéric Maxime Vaz, Joris J. T. H. Roelofs, Peter Boor, Martin Strauch, , Alessandra Tammaro

This study shows that chronic low-concentration PM2.5 exposure after ischemic injury accelerates CKD through mitochondrial dysfunction and lysosomal stress, with nicotinamide reversing some effects.

bioRxiv · Mar 14, 2026 · PreprintMolecular Biology

NNMT promotes tubular senescence and fibrosis in chronic kidney disease

Lucie Chanvillard, Hildo C. Lantermans, Christopher Wall, Jonathan Thévenet, Loes M. Butter, Loic Tauzin, Nike Claessen, Stefan Christen, Sonia Karaz, Steve Lassueur, Giulia Lizzo, José Luis Sanchez-Garcia, Sylviane Métairon, James A. Holzwarth, Valentina Ferro, , Alessandra Tammaro

This study identifies NNMT as a driver of tubular senescence and fibrosis in CKD, showing its association with senescence markers and protective effects when inhibited.

bioRxiv · Jan 6, 2025 · PreprintCell Biology