Georges E. Janssens

This study shows that chronic low-concentration PM2.5 exposure after ischemic injury accelerates CKD through mitochondrial dysfunction and lysosomal stress, with nicotinamide reversing some effects.

This study shows that young adipose-derived stem cell extracellular vesicles improve cardiac function and reduce aging-related damage in old mice.

The paper identifies plasma triacylglycerol (TG) length and saturation levels as markers of healthy aging in humans, showing that higher physical activity is linked to shorter TG chains and more double bonds.

The paper identifies atracurium as an FDA-approved compound that extends lifespan and healthspan in C. elegans by activating the FOXO/DAF-16 longevity pathway through neuromuscular acetylcholine receptor inhibition.

The paper identifies genes that suppress spontaneous mutation accumulation in yeast cells, finding PEX19 as an age-specific mutation suppressor.

This study shows glycine supplementation extends C. elegans lifespan and alters gene expression, with effects dependent on the methionine cycle.

This study shows that clk-1 mutations in C. elegans extend lifespan by repressing cytoplasmic protein translation, similar to insulin signaling reductions, and identifies TAF-4 as a repressor of polyribosome formation under these conditions.