Author

Alexander B. Smith

Children's Hospital of PhiladelphiaORCID 0000-0001-5407-0141Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Microbiology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Organism:C. elegans· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Organism:human· 1 Assay:metagenomics· 1

Frequent Co-Authors

Joseph P. ZackulariD· 2 shared Ashley S. WeissiD· 1 shared Debra N. BrunsoniD· 1 shared Haider S. ManzeriD· 1 shared Jilarie A. Santos-SantiagoiD· 1 shared Jose Abelardo C. LemosiD· 1 shared Montana KnightiD· 1 shared Orlaith KeenaniD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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Focal author (center)Selected co-authorORCID co-authorUnlinked name

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2 shared papersMicrobiology

Joseph P. ZackularORCID

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2 papers

Recent·Most cited

Enterococcus faecalis modulates phase variation in Clostridioides difficile

Ashley S. Weiss, Jilarie A. Santos-Santiago, Orlaith Keenan, Alexander B. Smith, Montana Knight, Joseph P. Zackular, Rita Tamayo

This study shows Enterococcus faecalis influences phase variation in Clostridioides difficile, altering its phenotypes through the CmrRST system.

Journal of Bacteriology · Dec 23, 2025Peer-reviewedMicrobiology

A Novel Heme-Degrading Enzyme that Regulates Heme and Iron Homeostasis and Promotes Virulence in Enterococcus faecalis

Debra N. Brunson, Haider S. Manzer, Alexander B. Smith, Joseph P. Zackular, Todd O. Kitten, Jose Abelardo C. Lemos

This study identifies a novel heme-degrading enzyme in Enterococcus faecalis that enables anaerobic heme degradation, iron acquisition, and virulence.

bioRxiv · Jan 20, 2025 · PreprintMicrobiology