NeuroscienceThe EMBO JournalPeer-reviewed
Preventing Jacob-induced transcriptional inactivation of CREB protects synapses from β-amyloid in Alzheimer's Disease
Katarzyna M. Grochowska, Guilherme M. Gomes, Rajeev Raman…·Michael R. Kreutz
The paper shows that Nitarsone prevents Aβ-induced CREB inactivation and synaptic loss in AD models by blocking Jacob-mediated signalosome assembly.
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