Author

PingAn Yuanxiang

Leibniz Institute for NeurobiologyORCID 0000-0002-3746-3282Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Anna KarpovaiD· 3 shared Guilherme M. GomesiD· 3 shared Michael R. KreutziD· 3 shared Christina SpilkeriD· 2 shared Gonca BayraktariD· 2 shared Oliver StorkiD· 2 shared Rajeev RamaniD· 2 shared Alessandro D. Confettura· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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3 shared papersNeuroscience

Anna KarpovaORCID

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3 papers

Recent·Most cited

Preventing Jacob-induced transcriptional inactivation of CREB protects synapses from β-amyloid in Alzheimer's Disease

Katarzyna M. Grochowska, Guilherme M. Gomes, Rajeev Raman, Rahul Kaushik, Liudmila Sosulina, Hiroshi Kaneko, Anja Maria Oelschlegel, PingAn Yuanxiang, Irene Reyes‐Resina, Gonca Bayraktar, Sebastian Samer, Christina Spilker, Marcel S. Woo, Markus Morawski, Jürgen Goldschmidt, , Michael R. Kreutz

The paper shows that Nitarsone prevents Aβ-induced CREB inactivation and synaptic loss in AD models by blocking Jacob-mediated signalosome assembly.

The EMBO Journal · Jan 3, 2023Peer-reviewedNeuroscience

Synaptic control of DNA-methylation involves activity-dependent degradation of DNMT3a1 in the nucleus

Gonca Bayraktar, PingAn Yuanxiang, Alessandro D. Confettura, Guilherme M. Gomes, Syed A. Raza, Oliver Stork, Shoji Tajima, Isao Suetake, Anna Karpova, Ferah Yildirim, Michael R. Kreutz

This study shows that synaptic activity controls DNA methylation by degrading DNMT3a1 via NMDAR-dependent neddylation.

Neuropsychopharmacology · Jul 29, 2020Peer-reviewedNeuroscience

SIPA1L2 controls trafficking and signaling of TrkB-containing amphisomes at presynaptic terminals

Maria Andres‐Alonso, Mohamed Raafet Ammar, Ioana Butnaru, Guilherme M. Gomes, Gustavo Acuña Sanhueza, Rajeev Raman, PingAn Yuanxiang, Maximilian Borgmeyer, Jeffrey Lopez‐Rojas, Syed Ahsan Raza, Nicola Brice, Torben Johann Hausrat, Tamar Macharadze, Silvia Diaz-Gonzalez, Mark B. L. Carlton, , Michael R. Kreutz

This study shows SIPA1L2 connects TrkB-containing amphisomes to dynein for retrograde trafficking and local signaling at presynaptic terminals, essential for BDNF-dependent plasticity.

Nature Communications · Nov 29, 2019Peer-reviewedNeuroscience