Shubhra Ganguli

This paper shows that 5-InsP7, synthesized by IP6K1, disrupts RAD51 binding to BRCA2-CTD, promoting DNA repair by dislodging RAD51 from DNA damage sites.

The paper shows that IP6K1 interacts with proteins that undergo pyrophosphorylation and with CK2, enabling coordinated pre-phosphorylation and pyrophosphorylation of target serine residues.

This study shows that acetylation of catalytic lysine in CDK1 regulates Cyclin-B binding, with SIRT1 and P300 opposing this modification, and that acetylation mimics in yeast block cell cycle progression.