Joan Sesing Lenz

Minimal Correlation but Complementary Diagnostic Utility for Plasma Cell-free RNA and Proteins

The paper compares plasma cell-free RNA and protein levels in children with inflammatory diseases, finding minimal correlation but similar diagnostic utility for distinguishing Kawasaki Disease from MIS-C.

Plasma Cell-Free RNA Captures Immune Dynamics and Predicts GVHD after Hematopoietic Stem Cell Transplantation

This study uses plasma cell-free RNA profiles to monitor immune dynamics and predict graft-versus-host disease (GVHD) after hematopoietic stem cell transplantation.

A metagenomic DNA sequencing assay that is robust against environmental DNA contamination

The paper introduces Coffee-seq, a metagenomic DNA sequencing method that reduces environmental contamination, and applies it to detect infections and microbial signatures in clinical samples.

Cell-Free DNA in Blood Reveals Significant Cell, Tissue and Organ Specific injury and Predicts COVID-19 Severity

This study uses cell-free DNA methylation profiling in plasma to identify organ-specific injury and predict COVID-19 severity in hospitalized patients.

Cell-free DNA Profiling Informs Major Complications of Hematopoietic Cell Transplantation

This study demonstrates that cell-free DNA analysis can detect multiple post-transplant complications in HCT recipients through methylation, metagenomic, and genomic profiling.

Separating the signal from the noise in metagenomic cell-free DNA sequencing

The paper introduces LBBC, a tool to reduce noise in metagenomic cfDNA sequencing, improving detection of urinary tract infection while minimizing false positives.