Author

Robert J. Soiffer

Dana-Farber Cancer InstituteORCID 0000-0002-5810-1192Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Research Focus:cell type annotation· 2 Approach:deep learning· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:scRNA-seq· 2 Assay:ATAC-seq· 1 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

Catherine J. WuiD· 3 shared Jerome RitziD· 3 shared Andrew A. LaneiD· 2 shared John KorethiD· 2 shared Kenneth J. LivakiD· 2 shared Shuqiang LiiD· 2 shared Alaa Kassim AliiD· 1 shared Alice CheniD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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3 shared papersCancer Biology

Catherine J. WuORCID

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Author profile →

3 papers

Recent·Most cited

Tumor-tropic E. coli engineered as living T and NK cell engagers

Shaobo Yang, Anna Clara Bader, Stephanie Sendker, Ashley Hu, Daniel Chuyang Chen, Hetal Nath, Alice Chen, Eden Bobilev, Michal Sheffer, Veronica W. Hui, Tereza Kochs, Andreia Maia, Jiting Tang, Fuguo Liu, Xingyu Deng, , Rizwan Romee

This paper develops LIME, a bacterial platform that engagers T and NK cells to target tumors, showing enhanced cytotoxicity and immune response in preclinical models.

bioRxiv · Aug 20, 2026 · PreprintBioengineering

Early persistence of recipient stem-cells and T-cell dysregulation are associated with relapse after transplant in AML/MDS

Nurefsan E. Sariipek, Ksenia R. Safina, Wesley S. Lu, Shuqiang Li, J. Thomas Janes, McKayla Van Orden, Kenneth J. Livak, Haynes Heaton, Vincent T. Ho, John Koreth, Marlise Rachael Luskin, Gabriel Kenneth Griffin, Jacqueline Suen Garcia, Robert Coleman Lindsley, Corey S. Cutler, , Peter van Galen

The paper identifies recipient stem-cell persistence and T-cell dysregulation as predictors of relapse after HSCT in AML/MDS by analyzing single-cell RNA and TCR sequencing data.

bioRxiv · Nov 13, 2025 · PreprintCancer Biology

ASXL1 truncating mutations drive leukemic resistance to T cell attack

Dustin McCurry, Zhongqi Ge, Jaehyun Lee, Rishi Pasumarthi, Xiaohong Leng, Thomas Köhnke, Oren Pasvolsky, Pranaya Raparla, Vinhkhang N. Nguyen, Katie Maurer, Shuqiang Li, Kenneth J. Livak, Emerie E Danson, Bijal Thakkar, Elham Azizi, , Pavan Bachireddy

This study identifies ASXL1 truncating mutations as a driver of leukemic resistance to T cell attack and proposes EZH2 inhibition as a therapeutic strategy to overcome this resistance.

bioRxiv · May 29, 2025 · PreprintCancer Biology