Lindsay A. Farrer

The paper identifies novel genetic loci associated with nicotine dependence and shows genetic correlations with other smoking traits and comorbidities using genome-wide association studies.

This study uses Mendelian randomization to assess causal relationships between 22 risk factors and the Alzheimer's phenome, finding education, blood pressure, cholesterol, smoking, and BMI have causal effects.

This study identifies genetic variants and pathways associated with cognitive resilience to Alzheimer's disease, finding a novel locus linked to bile acid metabolism and methylation changes.

The paper compares genome-wide data from opioid use and dependence cases to identify genetic associations and differences between exposure and dependence.

This study identifies genetic variants associated with self-reported childhood maltreatment and finds significant genetic correlations with depressive symptoms.

This study uses machine learning to identify factors associated with opioid cessation in individuals with OUD, finding that less recent cocaine use, shorter opioid duration, and older age are strongest predictors.

This study demonstrates sex-dependent polygenic effects on Alzheimer’s disease progression by using polygenic hazard scores, showing stronger associations with clinical outcomes than traditional polygenic risk scores.

This study conducts the largest GWAS for PTSD, identifying 6 genome-wide significant loci in European and African ancestries and highlighting novel biological pathways.

Genetic correlations across 25 brain disorders (215,683 cases) reveal broad psychiatric common-variant sharing, largely distinct neurological disorders, and migraine as the only significant cross-category link.

This study identifies a haplotype lowering PU.1 expression in myeloid cells that delays Alzheimer’s disease onset by affecting gene expression and function.

This paper develops and validates a polygenic hazard score to predict age-specific Alzheimer's disease risk using genetic data from multiple cohorts.