Single-molecule analysis reveals the rapid effect of estradiol on the surface movement of AMPAR in live neurons
Soma Godó, Klaudia Barabás, Ferenc Lengyel, Dávid ErnsztiD, Tamás Kovács, Miklós KecskésiD, Csaba VargaiD, Tibor Zoltán Jánosi, Gergely Kovács, Barbara OrsolitsiD, Takahiro K FujiwaraiD, Akihiro KusumiiD, István M. ÁbrahámiD
Abstract
The gonadal steroid 17{beta}-estradiol (E2) rapidly alters glutamatergic neurotransmission, but its direct effect on the AMPA receptor (AMPAR) remains unknown. Live-cell single-molecule imaging experiments revealed that E2 rapidly and dose-dependently alters the surface movement of AMPAR via membrane estrogen receptors with distinct effects on somas and neurites. The effect of E2 on the surface mobility of AMPAR depends on the integrity of the cortical actin network.
02 /Specification & Classification
Click any tag to browse matching papers- Citations
- 0
- Assay
- Approach
Reproducibility ledger
Nobody has reported trying to reproduce this paper yet. Did you replicate an experiment or run the code? Your report saves the next lab a week.
Sign in to file a reproducibility report.
Related papers
- Phosphorylation of AMPA receptor subunit GluA1 regulates clathrin-mediated receptor endocytosis
Matheus Figueiredo Sathler, Latika Khatri, … Seonil Kim·Journal of Cell SciencePeer-reviewed·Aug 9, 2021
- Reactive Oxygen Species Modulate Activity-Dependent AMPA Receptor Transport in C. elegans
Rachel L. Doser, Gregory C. Amberg, Frédéric J. Hoerndli·Journal of NeurosciencePeer-reviewed·Aug 26, 2020
- PKD promotes activity-dependent AMPA receptorendocytosis in hippocampal neurons
Carlos Omar Oueslati Morales, Attila Ignácz, … Angelika Haußer·TrafficPeer-reviewed·Sep 26, 2021
- Plasticity-induced actin polymerization in the dendritic shaft regulates intracellular AMPA receptor trafficking
Victor C. Wong, Patrick R. Houlihan, … Erin K. O’Shea·eLifePeer-reviewed·Jul 10, 2024
- High-resolution imaging and manipulation of endogenous AMPA receptor surface mobility during synaptic plasticity and learning
Angela M. Getz, Mathieu G. Ducros, … Daniel Choquet·Science AdvancesPeer-reviewed·Jul 27, 2022
- Gating transitions and modulation of a hetero-octameric AMPA glutamate receptor
Danyang Zhang, Jake F. Watson, … Ingo H. Greger·NaturePeer-reviewed·Jun 2, 2021