Matilde Bertolini

Translation-driven temporal control for intertwined protein assembly

The paper reveals a temporal control mechanism driven by coupled ribosomes that enables the formation of intertwined protein dimers by bypassing closed monomeric states.

Co-translational ribosome pairing enables native assembly of misfolding-prone subunits

The paper shows co-translational ribosome pairing enables the formation of coiled-coil homodimers from misfolding-prone subunits through chaperone-like interactions between nascent chains.

Macrocyclic phage display for identification of selective protease substrates

This paper introduces a method using macrocyclic phage display to identify selective protease substrates, demonstrating its effectiveness with FAP and DPP4.

Identification of Covalent Cyclic Peptide Inhibitors Targeting Protein-Protein Interactions Using Phage Display

This paper identifies covalent cyclic peptide inhibitors targeting protein-protein interactions using phage display, demonstrating antiviral activity against SARS-CoV-2.

Interferon regulates stem cell function at all ages by orchestrating mTOR and cell cycle

This study shows interferon regulates stem cell function across all ages by controlling mTOR and cell cycle, with beneficial effects in youth and harmful effects in aging brains.