Jennifer W. Gin

This paper uses a genomic language model to design and optimize a synthetic biosynthetic pathway for producing a non-natural molecule, achieving a 9.4-fold increase in production.

This paper introduces a carbon cofeeding strategy to overcome stoichiometric limitations in redox-balance growth coupling, enabling growth-coupled selection for biosynthetic pathways in engineered E. coli.

The paper uses a biosensor-driven strategy to enhance isoprenol production in Pseudomonas putida through combinatorial strain engineering and omics analysis.

This paper trains a deep learning model on multiomics data to predict metabolic dynamics in synthetic biology, achieving high accuracy in predicting product and metabolite levels.

This study uses adaptive laboratory evolution and rational engineering to improve Pseudomonas putida's tolerance to isoprenol, enhancing its production of a sustainable aviation fuel precursor.

This study introduces two methods, FluxRETAP and VAMMPIRE, to improve CRISPRi-mediated gene downregulation for bioproduction by enhancing target identification and multiplexed construct assembly.

This paper develops acetate-tolerant Pseudomonas putida strains for isoprenol production using mixed carbon sources and identifies molecular mechanisms underlying tolerance and production.

This paper introduces a modular polyketide synthase platform for producing diols, amino alcohols, and hydroxyacids using engineered Streptomyces albus strains.

This study identifies fumarate hydratase activity as a bottleneck in a genome-scale metabolic model design for bioproduction from para-coumarate, requiring optimization for growth and product formation.

The paper develops growth-coupled microbial strains for high-yield indigoidine production using iterative engineering and computational evaluation.

This paper engineers Pseudomonas putida for isoprenol production using computational modeling and strain optimization, achieving a titer of 3.5 g/L.

This paper introduces a yeast platform for producing bacterial aromatic polyketides using a synthetic polyketide synthase system.