Bottlenecks in the Implementation of Genome Scale Metabolic Model Based Designs for Bioproduction from Aromatic Carbon Sources
Deepanwita Banerjee, Javier Menasalvas, Yan Chen, Jennifer Gin, Edward E. K. Baidoo, Christopher J. Petzold, Thomas Eng, Aindrila Mukhopadhyay
This study identifies fumarate hydratase activity as a bottleneck in a genome-scale metabolic model design for bioproduction from para-coumarate, requiring optimization for growth and product formation.
npj Systems Biology and Applications · Jan 14, 2025Peer-reviewedMicrobiology