James W. McCormick

This study shows that inserting a domain into a protein's sector-connected surface increases the likelihood of evolving allosteric regulation, while non-sector-connected sites are less evolvable.

This study identifies nine novel P-gp inhibitors using a computationally accelerated drug discovery pipeline, showing they reverse multidrug resistance in cancer cells with minimal toxicity to non-cancerous cells.

This study investigates how domain insertion in a synthetic enzyme fusion enables light-induced allosteric regulation through localized conformational changes and bidirectional domain coupling.