David Ish‐Horowicz

This study identifies Syncrip/hnRNPQ as a regulator of activity-induced Msp300/Nesprin-1 expression and new synapse formation through local translation.

The paper shows that Imp/IGF2BP regulates neural stem cell growth and division in Drosophila by stabilizing myc mRNA, affecting cell size and division rates.

The paper shows that larval neurons upregulate Prospero protein through alternative polyadenylation and Syncrip-mediated mRNA stabilization.

The paper identifies Greb1 as essential for axial elongation and segmentation in vertebrate embryos, showing its role in maintaining axial progenitors and regulating the segmentation clock.

This paper applies single-molecule FISH to study post-transcriptional regulation in Drosophila brains by analyzing mRNA distributions and co-visualizing transcripts and proteins.

The paper shows that Imp and Syp RNA-binding protein gradients control the timing of Drosophila neuroblast decommissioning by regulating Prospero accumulation and mediator complex activity.