Seth M. Tomchik

Loss of neurofibromin alters adult metabolism via effects during a developmental critical period

This study shows that loss of Nf1 in neurons during a critical developmental period causes adult metabolic changes in Drosophila, without affecting mitochondrial function.

Metabolic and behavioral effects of neurofibromin result from differential recruitment of MAPK and mTOR signaling

This study investigates how neurofibromin mutations affect metabolic and behavioral traits in Drosophila by analyzing the roles of MEK and Akt/mTOR signaling pathways.

Neurofibromin deficiency alters the patterning and prioritization of motor behaviors in a state-dependent manner

This study shows that reduced Nf1 expression in Drosophila alters motor behavior patterns and prioritization, but not motor coordination, in a state-dependent manner.

Neurofibromin 1 mediates sleep depth in Drosophila

This study investigates the role of Neurofibromin 1 (Nf1) in regulating sleep depth and metabolic rate in Drosophila, finding that Nf1 deficiency disrupts sleep consolidation and gut homeostasis.

Associative learning drives longitudinally-graded presynaptic plasticity of neurotransmitter release along axonal compartments

The paper shows that associative learning induces compartmentalized, bidirectional plasticity of acetylcholine release in Drosophila mushroom body axons, with valence-dependent effects and distinct molecular mechanisms.

Neurofibromin regulates metabolic rate via neuronal mechanisms in Drosophila

This study shows that dNf1 in Drosophila regulates metabolic rate through neuronal mechanisms, with effects on feeding, lipid stores, and energy expenditure.