Elizabeth Brown

This study shows that artificial selection on cuticle color in Drosophila species leads to correlated changes in aggression and basal activity, but not in other behaviors.

This study shows that sleep restoration in aged Drosophila improves glial clearance of damaged axons by restoring Draper expression and transcriptional responses to injury.

This study investigates how sleep at different life stages affects longevity in Drosophila, finding that early life sleep is positively associated with longer lifespan.

The paper identifies genes regulating sleep-metabolism interactions in Drosophila LHLK neurons using single-cell sequencing and functional validation.

This study shows aging impairs sugar taste response in fruit flies, but not fatty acids, and links this to specific neuronal changes and AD-like mechanisms.

This study investigates the role of Neurofibromin 1 (Nf1) in regulating sleep depth and metabolic rate in Drosophila, finding that Nf1 deficiency disrupts sleep consolidation and gut homeostasis.

This study identifies rs3752495 as the causal variant at the insomnia WDR90 GWAS locus that influences PIG-Q expression through a regulatory mechanism.

The paper identifies GPI-anchor biosynthesis as a conserved regulator of sleep through variant-to-gene mapping and cross-species genetic screening in humans and model organisms.

The paper identifies conserved genes at insomnia GWAS loci using zebrafish CRISPR screens and chromatin interaction data, finding that MEIS1 and SKIV2L mutations produce insomnia-like behaviors.

This paper measures metabolic rate in single Drosophila during sleep and waking states using indirect calorimetry and finds that metabolic rate decreases during sleep and is reduced in aging flies.

This study shows that dNf1 in Drosophila regulates metabolic rate through neuronal mechanisms, with effects on feeding, lipid stores, and energy expenditure.

The paper shows Drosophila can distinguish between different fatty acid classes using aversive memory assays, with Ir56d neurons playing a key role in medium-chain fatty acid detection.

This study shows that monarch caterpillars exhibit increased aggression under low food availability, suggesting resource defense as a trigger for aggressive behavior.

This study identifies Dilp2 as essential for regulating sleep depth in response to starvation, revealing distinct mechanisms for sleep duration and depth homeostasis in Drosophila.

This study shows dietary fatty acids increase sleep in fruit flies through a taste-independent mechanism.

This study shows that selection for starvation resistance in Drosophila melanogaster leads to delayed development and reduced metabolic rate in larvae, which persist into adulthood, along with changes in feeding and sleep behavior.

This study identifies Ade2 as a gene in Drosophila fat body that promotes sleep and energy storage through RNAi screening and genetic analysis.

The paper identifies IR56d-expressing neurons as necessary and sufficient for fatty acid taste in Drosophila, showing they mediate feeding responses and distinguish FA from sugar.