Nathaniel C. Noyes

Pharmacological rescue of mitochondrial dysfunction, neurite degeneration, and premature death of ALS and AD iPSC-derived neurons

This study identifies Dipyridamole as a drug that rescues mitochondrial dysfunction and neuronal death in ALS and AD iPSC-derived neurons by enhancing mitochondrial pyruvate uptake.

Associative learning drives longitudinally-graded presynaptic plasticity of neurotransmitter release along axonal compartments

The paper shows that associative learning induces compartmentalized, bidirectional plasticity of acetylcholine release in Drosophila mushroom body axons, with valence-dependent effects and distinct molecular mechanisms.