Laura Riva

This study analyzes mouse skin tumors to determine how environmental factors like TPA, obesity, and wounding affect mutational burden and cancer risk, finding that tumor promoters, not mutation number, limit tumor growth.

SigProfilerExtractor is a tool for de novo mutational signature extraction that outperforms existing methods and identifies four novel signatures, including one linked to tobacco smoking.

The paper analyzes whole-genome sequencing data from melanoma metastases to show that branched evolution is common and that subclonal heterogeneity is prevalent in metastatic melanoma.