Pharmacology & ToxicologyEuropean Journal of Medicinal ChemistryPeer-reviewed
Development of GS-441524 Derivatives as Potent SARS-CoV-2 Mac1 Inhibitors via a Direct-to-Biology Approach
Kewen Peng, Suryadeep Chakraborty, Shamar D. Wallace…·Hening Lin
The paper develops potent SARS-CoV-2 Mac1 inhibitors through a direct-to-biology approach, improving the potency of GS-441524 to KP-S54 with IC50 values of 44 nM and 91 nM against SARS-CoV-2 and MERS-CoV Mac1, respectively.
DOI 10.1016/j.ejmech.2026.119280