Annette Choi

Development of GS-441524 Derivatives as Potent SARS-CoV-2 Mac1 Inhibitors via a Direct-to-Biology Approach

The paper develops potent SARS-CoV-2 Mac1 inhibitors through a direct-to-biology approach, improving the potency of GS-441524 to KP-S54 with IC50 values of 44 nM and 91 nM against SARS-CoV-2 and MERS-CoV Mac1, respectively.

SARS-CoV-2 serosurvey of healthy, privately owned cats presenting to a New York City animal hospital in the early phase of the COVID-19 pandemic (2020-2021)

This study reports a serosurvey of cats in New York City during the early pandemic, finding 16% seropositive for SARS-CoV-2 with higher prevalence in fall 2020 and evidence of human-cat transmission.

Deletion of a KSF Motif Attenuates NSP1 Host Cell Translation Shutoff and Impairs SARS-CoV-2 Virulence

This study shows that a deletion in the NSP1 protein of SARS-CoV-2 variants reduces virulence by impairing host translation shutoff, suggesting NSP1 as a target for antiviral strategies.

Enhanced RNA replication and pathogenesis in recent SARS-CoV-2 variants harboring the L260F mutation in NSP6

This study identifies the L260F mutation in NSP6 as enhancing RNA replication and pathogenesis in recent SARS-CoV-2 variants, independent of Spike function.

Molecular basis of pathogenicity of the recently emerged FCoV-23 coronavirus

This study identifies molecular mechanisms of FCoV-23 pathogenicity, including receptor usage and biotype switching, and identifies a cross-reactive antibody for therapeutic development.

Inhibiting Glutamine Metabolism Blocks Coronavirus Replication in Mammalian Cells

The paper shows that inhibiting glutaminase enzymes blocks coronavirus replication in mammalian cells, suggesting these inhibitors as potential anti-viral drugs.