Author

Kewen Peng

Cornell UniversityORCID 0000-0003-0791-6372Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2

Frequent Co-Authors

Hening LiniD· 2 shared Suryadeep Chakraborty· 2 shared Annette ChoiiD· 1 shared gary whittaker· 1 shared J. Christopher FrommeiD· 1 shared Jéssica Caroline Gomes NolliD· 1 shared Jialin Shang· 1 shared Shamar D. WallaceiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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2 shared papersPharmacology & Toxicology

Hening LinORCID

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2 papers

Recent·Most cited

Pharmacology & ToxicologyEuropean Journal of Medicinal ChemistryPeer-reviewedAug 28, 2026

Development of GS-441524 Derivatives as Potent SARS-CoV-2 Mac1 Inhibitors via a Direct-to-Biology Approach

Kewen Peng, Suryadeep Chakraborty, Shamar D. Wallace…·Hening Lin

The paper develops potent SARS-CoV-2 Mac1 inhibitors through a direct-to-biology approach, improving the potency of GS-441524 to KP-S54 with IC50 values of 44 nM and 91 nM against SARS-CoV-2 and MERS-CoV Mac1, respectively.

DOI 10.1016/j.ejmech.2026.119280

experimental assaydrug response / drug discovery

𝕏 PostBluesky

BiochemistryACS Chemical BiologyPeer-reviewedApr 17, 2026

A High-throughput Fluorescence Polarization Assay for Screening Sirtuin Inhibitors

Kewen Peng, Suryadeep Chakraborty, Yizhen Jin, Hening Lin

The paper develops a high-throughput fluorescence polarization assay to screen SIRT1-3 inhibitors, showing improved efficiency and performance compared to existing methods.

DOI 10.1021/acschembio.6c00205

experimental assaydrug response / drug discovery

𝕏 PostBluesky

Kewen Peng · henhao