Alain Jacquier

The paper performs large-scale genetic interaction screens in yeast to study RNA metabolism, identifying gene links to biological processes and validating a specific connection to mRNA translation initiation.

The paper shows that ncRNA degradation by the exosome is necessary for recycling termination factors, and defects in this process lead to termination issues at NNS targets.

The paper identifies Ska1 as a SKI complex subunit that specifically mediates degradation of ribosome-free RNA regions, revealing a model for SKI complex function in mRNA decay.

The paper shows that antisense transcription represses up to 30% of the least expressed genes in budding yeast, particularly those enriched in quiescence.

The paper identifies two distinct Upf1-bound complexes in yeast NMD, Detector and Effector, and shows their roles in substrate detection and degradation.