Emmanuel Frachon

An in vitro human vessel to study Neisseria meningitidis colonization and vascular damages

This paper develops a 3D microfluidic model to study Neisseria meningitidis colonization and vascular damage, showing it replicates in vivo infection features with higher resolution than animal or 2D models.

In-vitro cellular reprogramming to model gonad development and its disorders

This paper describes in-vitro protocols to differentiate mouse and human pluripotent cells into gonadal progenitors, revealing their functional equivalence to in-vivo cells and modeling DSDs.

Investigation of RNA metabolism through large-scale genetic interaction profiling in yeast

The paper performs large-scale genetic interaction screens in yeast to study RNA metabolism, identifying gene links to biological processes and validating a specific connection to mRNA translation initiation.