Domenico Libri

The paper identifies mutational signatures caused by DNA:RNA hybrids in yeast genomes, revealing a common mechanism of genetic instability through repair pathways.

The paper shows DNA supercoiling inhibits transcriptional bursting of neighboring genes in yeast, differing from bacterial mechanisms.

This study shows that the m6A-reader Pho92 in S. cerevisiae promotes meiotic progression by accelerating the down-regulation of specific mRNAs during meiotic recombination.

The paper shows Sen1 resolves transcription-driven conflicts and maintains genomic stability by terminating non-coding transcription and resolving R-loops.

The paper investigates RNAPIII transcription termination in budding yeast, showing T-tracts are necessary but not sufficient, and secondary structures and Sen1 helicase are important for termination.

This study investigates how Xrn1 affects transcription elongation in yeast by analyzing RNA polymerase II profiles and chromatin structure.

The paper shows that ncRNA degradation by the exosome is necessary for recycling termination factors, and defects in this process lead to termination issues at NNS targets.

The paper identifies a CTD-mimic motif in Sen1 that interacts with Nrd1's CTD-interacting domain to facilitate ncRNA termination in yeast.

The paper investigates how opposing chromatin remodelers influence transcription initiation frequency and start site selection in budding yeast by analyzing their binding and nucleosome displacement activity.

The paper shows pervasive transcription affects replication origin activity in budding yeast by pausing and terminating RNAPII transcription near origins.

This study shows that General Regulatory Factors like Rap1 suppress ectopic transcription initiation and maintain nucleosome positioning, ensuring transcription fidelity in yeast.