Abdelkader Namane

The paper shows that mRNA stability in yeast is determined by decapping speed, not deadenylation rate, with unstable mRNAs having rapid decapping and longer poly(A) tails.

The paper uses cryo-EM to characterize native ABCE1-containing pre-initiation complexes in yeast and human cells, revealing their structural roles in translation initiation.

The paper identifies Ska1 as a SKI complex subunit that specifically mediates degradation of ribosome-free RNA regions, revealing a model for SKI complex function in mRNA decay.

The paper identifies two distinct Upf1-bound complexes in yeast NMD, Detector and Effector, and shows their roles in substrate detection and degradation.

The paper shows that actin activates ExoY and ExoY-like cyclases from pathogens, revealing a new class of actin-activated nucleotidyl cyclase toxins.