Jean Christophe Poncer

This study identifies two compounds that enhance KCC2 function, reducing interictal activity and preventing seizures in mesial temporal lobe epilepsy.

This study shows KCC2a regulates KCC2b function differently in developing and mature cortical neurons, acting as a developmental switch for synaptic inhibition.

This study examines how mutations in Kv2.1, a potassium channel linked to epileptic encephalopathy, affect channel clustering and neuronal excitability, finding impaired clustering but no change in excitability.

This study shows that silencing KCC2 in the mouse dorsal hippocampus impairs spatial and contextual memory, linked to altered brain rhythms and neuronal hyperexcitability.

This study investigates chloride regulation by cation-chloride cotransporters in mouse hippocampal parvalbumin interneurons and pyramidal cells, showing similar mechanisms and the critical role of KCC2 in maintaining inhibitory GABA signaling.

This study shows that KCC2 downregulation in rat dentate gyrus leads to increased neuronal excitability and altered network activity through interactions with Task-3 channels.