Enhancing KCC2 function reduces interictal activity and prevents seizures in mesial temporal lobe epilepsy
Florian Donneger, Adrien Zanin, Jeremy Besson, Delphine Roussel, Yoness Kadiri, Carla Pagan, Manisha Sinha, Nicolas David, Marion Russeau, Franck Bielle, Bertrand C. Devaux, Bertrand Mathon, Vincent Navarro, Francine Chassoux, Jean Christophe Poncer
This study identifies two compounds that enhance KCC2 function, reducing interictal activity and preventing seizures in mesial temporal lobe epilepsy.
Proceedings of the National Academy of Sciences · Mar 3, 2026Peer-reviewedNeuroscience