Lorenzo Giacani

This study develops a human epithelial co-culture system that supports Treponema pallidum growth and identifies two distinct host-cell interaction behaviors.

This study analyzes Treponema pallidum strains in Buenos Aires, Argentina, using whole genome sequencing and tprK locus analysis to understand transmission dynamics and lineage-specific diversity.

This study identifies TprD and TprK as surface-exposed adhesins on Treponema pallidum that mediate cell adherence and are targets of opsonic antibodies promoting macrophage-mediated clearance.

The paper shows three T. pallidum isolates with Tp0705 PBP polymorphisms are equally susceptible to penicillin G and ceftriaxone.

This paper introduces a new MLST scheme for Treponema pallidum subspecies with high discriminatory power, validated using global clinical samples and showing distinct genetic clusters.

The paper introduces genetically encoded fluorescent tags for Treponema pallidum and Sf1Ep cells to enhance visualization and study host-pathogen interactions in syphilis research.

This study develops a pan-proteome array to profile the humoral response to Treponema pallidum in rabbits, identifying antigens for early diagnosis and vaccine development.

This study shows that long-term in vitro exposure of Treponema pallidum to sub-bactericidal doxycycline does not induce resistance, supporting the use of doxy-PEP for syphilis prevention.

The paper identifies Tp-specific CD4+ T cell responses in blood and skin of syphilis patients, showing persistence after treatment and highlighting potential vaccine targets.

The paper analyzes Treponema pallidum genomic data from Seattle to identify strain circulation and tprK antigen variation patterns in syphilis cases.

This study analyzes the genetic patterns of modern syphilis strains and identifies a globally dominant pandemic cluster with azithromycin resistance.