Veronika Petrova

ASPEN improves detection of allelic dynamics in single-cell RNA-seq by modeling mean and variance, revealing patterns of allelic imbalance and variance in mouse cells.

The paper develops a mouse cortical organoid platform to study cis-regulatory evolution and identifies genes with dynamic allelic imbalances during neurogenesis.

The paper identifies a link between the emergence of new enhancers and late DNA replication regions in mammals, showing increased tissue specificity and TF binding in these regions.

The paper shows that chromatin accessibility influences cell-type specific intron retention and confirms intrinsic intron features affect splicing.

The paper shows that chronic myeloid leukemia patients in molecular remission still have widespread aberrant alternative splicing, unlike normal gene expression and DNA methylation patterns.